To evaluate the efficacy and safety of CartiNovex plus tablet in osteoarthritis and rheumatoid arthritis

Interminable arthritis issue, for example, osteoarthritis [OA] and rheumatoid arthritis [RA] have in like manner an upsurge of aggravation, and oxidative anxiety, bringing about dynamic histological modifications and incapacitating indications. As of now utilized allopathic prescription [extending from painkiller executioners to natural operators] is intense, yet regularly connected with genuine, even dangerous symptoms. Utilized for centuries in customary herbalism, restorative plants are a promising option, with bring down rate of unfavorable occasions and productivity every now and again tantamount with that of traditional medications. In any case, their instrument of activity is as a rule smooth and additionally indeterminate. Despite the fact that a large number of them have been demonstrated powerful in ponders done in vitro or on creature models, there is a shortage of human clinical proof. This clinical trial was conducted at Liaquat National Hospital, Karachi, Pakistan. This was a single blind, placebo control phase II clinical trial. Total 200 patients were enrolled in the study, in which 110 received the CartiNovex plus tablet and 90 received the placebo. The age range of patients was 40 years to above 70 years. The sample paired t-test was applied to evaluate the significant level. Different parameters like pain on sitting or lying, morning stiffness, pain on walking, stiffness in sitting, lying or resting later in the day, getting on/off toilet, light domestic duties [such as tidying room, dusting, cooking], WOMAC score % were tested for both group i.e. CartiNovex plus group and placebo group in all parameters CartiNovex plus show significant improvement in all parameters. CartiNovex plus tablet was very effective in the management of OA and RA. The CartiNovex plus tablet was safe and well tolerated in all patients and side effects are non-significant

Conversion from Laproscopic Cholecystectomy to open Cholecystectomy when and why?

In this study 450 patients presented with symptomatic cholelithiasis, under went Laproscopic cholecystectomy from 1-1-2003 to 30-6-2004.Sex ratio showed that 92% were female and 8% male patients. Most of the cases 44% are in the age group 40-49 years. About 74% patients had chronic cholecystitis while 15% had acute cholecystitis. Mucocoele was present in 6%and empyema in 5% of cases. Conversion from laproscopic to open cholecystsectomy was done in 14 patients i.e 3.11%. The reason for conversion among these patients was acute cholecystitsis in 1.33% and anatomy was not clear. Heamorrhage occurred in 0.88%, empyema gall bladder with thickened, odematous gall bladder in 0.66% cases. Hypotention occurred in one patient

Percutaneous renal biopsy by automated biospsy gun

To study the safety and efficacy of automated biopsy gun in obtaining the renal tissue by percutaneous renal biopsy. Design: Single centered prospective hospital based study. Place and Duration of Study: Department of Medicine, Unit II, Lahore General Hospital, Lahore for more than one year from January 2000 to February 2001. Subjects and Forty patients of either gender having clinical features of renal disease with overt proteinuria were included in the study. An informed consent was taken from patients. Patients were lied prone, local anaesthesia was given at lower pole of left kidney. Renal biopsy was performed under ultrasound guidance, using 18G spring loaded automated biopsy gun. Majority of patients, 28[70%], was male. The mean age was 26.9 years with range of 5-70 years. In 37 [97.5%] patients successful biopsy was done while there was its failure in 3 [7.5%] patients. The average core length of renal tissue obtained was Mean'SD [1.02'0.34] cm with a mean number of glomeruli per core Mean'SD [7.76'2.36] and histopathological diagnosis was made in all cases. Total number of attempts were 1-3. In 70% patients single attempt was done. No major complication related to the procedure was seen. Renal biopsy with automated biopsy gun is relatively safe and effective in establishing the diagnosis of renal diseases. Although renal biopsy can be done on outpatient basis, it is better to observe the patients for 24 hours post-operatively for any complication

Hepatitis B vaccine: efficacy and immunogenicity

To evaluate the efficacy of anti-HB levels among health workers vaccinated with DNA recombinant Hepatitis B vaccine derived from Chinese Hamster ovary cells [CHO-cells]. A study of 20 subjects protected with anti-HB levels [>/= 10m 1 U/ml] were assessed. Setting: Department of Medicine, Lahore General Hospital. No non-responder and major adverse effects were identified in this study. CHO cells derived DNA recombinant Hepatitis B vaccine are effective in standard dose regime.However, further work is required to check the efficacy of low dose hepatitis B vaccination regimens using different routes of administration within the population. To decrease the cost of vaccines and screening tests, efforts should be made at national and international levels so that mass Hepatitis B immunisation programmes are initiated